Mendelian randomisation for nutritional psychiatry
نویسندگان
چکیده
منابع مشابه
Mendelian Randomisation: A Minireview
, © Wells This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and redistribution in any medium, provided that the original author and source are credited. Mendelian randomisation is a technique which, fuelled by the results of GWA studies, can be used to determine causal relationships between in...
متن کاملMendelian randomisation, lipids, and cardiovascular disease.
In The Lancet, Benjamin Voight and colleagues use mendelian randomisation analysis to invest igate the relation between HDL cholesterol and coronary heart disease. High HDL cholesterol concentration is associated with reduced risk of coronary heart disease in observational studies, but whether the association is causal cannot be unequivocally ascertained from these studies alone, and whether ra...
متن کاملOn the Bias of IV Estimators for Mendelian Randomisation
Mendelian randomisation is an instrumental variable method using a genetic variant as instrument to estimate the causal effect of exposure on disease in the presence of unobserved confounding. We discuss the modelling assumptions required by various estimators based on instrumental variables, particularly with regard to their plausibility for typical epidemiological studies. We further compare ...
متن کاملMendelian randomisation in cardiovascular research: an introduction for clinicians
Understanding the causal role of biomarkers in cardiovascular and other diseases is crucial in order to find effective approaches (including pharmacological therapies) for disease treatment and prevention. Classical observational studies provide naïve estimates of the likely role of biomarkers in disease development; however, such studies are prone to bias. This has direct relevance for drug de...
متن کاملMendelian randomisation: a tool for assessing causality in observational epidemiology.
Detection and assessment of the effect of a modifiable risk factor on a disease with view to informing public health intervention policies are of fundamental concern in aetiological epidemiology. In order to have solid evidence that such a public health intervention has the desired effect, it is necessary to ascertain that an observed association or correlation between a risk factor and a disea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Lancet Psychiatry
سال: 2020
ISSN: 2215-0366
DOI: 10.1016/s2215-0366(19)30293-7